For life sciences and regulated industry clients, contracts include a GxP addendum covering audit trail requirements, change control documentation, and validation support obligations where PYRANA is used in a GxP-adjacent context.

While PYRANA itself is not a validated system, some clients use it in workflows adjacent to GxP activities (e.g., capturing SOPs, batch record context). The addendum clarifies Zeroth Agents' role, documentation obligations, and the boundary between PYRANA and validated systems.